The cancer stem cell model, also known as the hierarchical model proposes that tumors are hierarchically organized cscs lying at the apex fig. Relationships bewteen promoter dna hypermethylation, genes which regulate stemprogenitor cells, and initiation of human cancer. Mar 15, 2019 after weathering the storm, cancer stem cells are able to divide and repopulate an entire tumor and even take road trips to create tumors in other areas of the body. Chapters include emerging provocative evidence that a cancer stem cell, although still necessarily defined operationally.
Instead, they help you recover your ability to produce stem cells after treatment with very high doses of radiation therapy, chemotherapy, or both. Relationships bewteen promoter dna hypermethylation, genes which regulate stem progenitor cells, and initiation of human cancer. Stem cells information for authors stem cells journals. Stem cells and cancer stem cells, volume 2 stem cells. The need to remove cancer cells from transplanted stem cells or transplant patients and the best way to do it continutes to be researched.
The realization that cancers may rely on cancer stem cells that share the selfrenewal feature of normal stem cells has changed the perspective with regard to new approaches for treating the disease. Oct 31, 2009 relationships bewteen promoter dna hypermethylation, genes which regulate stem progenitor cells, and initiation of human cancer. This book, the second in a planned series of 7 volumes, covers select new research in both. Only this small subpopulation of cells has the inherent ability to form tumors and metastasize. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis. The main goal of the book is to provide readers with an overview of the scientific facts about stem cells and its promising effects on the human body, as well as on the creation of new drugs and. Cancer stem cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how theyre generated, where they are localized, the means by. Cancer stem cells lucie laplane harvard university press. I praise the editor and the authors for this wonderful endeavor. Cancer stem cells theories and practice intechopen. Mar 11, 2008 cancer stem cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Doing 2 autologous transplants in a row is known as a tandem transplant or a double autologous transplant.
Mesenchymal stem cells in cancer therapy sheds light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells msc in various cancers with. This book, the second in a planned series of 7 volumes, covers select new research in both fields. Mesenchymal stem cells in cancer therapy sciencedirect. This book highlights selected research from renowned scientists around the world. With additional material on targeting selfrenewal pathways in cancer stem cells, the use of mesenchymal stem cells in treating ischemic brain injury, and the phenomenon of neural stem cell proliferation. A donor stem cell transplant replaces bone marrow that is not working properly with stem cells from another person a donor. Preface the cancer stem cell hypothesis kimberly e. Cancer stem cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how theyre generated, where they are localized, the. Research has shown that cancer cells are not all the same. Stem cells and cancer stem cells, volume 6 springerlink. Mar, 2020 stem cells in our bodies act as reservoirs of cells that divide to produce new stem cells, as well as a myriad of different types of specialized cells, required to secure tissue renewal and function. So, rafii says, if you dont get rid of those few cancer stem cellseven if you kill the other 95 percent of the tumorthen the cancer is going to continue to grow.
It discusses how the liver performs regeneration and repair, the role stem cells play in these processes. New finding reopens the book on colon cancer stem cells. In the past cancer researchers thought that cancer stem cells were only present in leukemia, largely because of a lack of testing methods for solid tumors. Unknown whether the tissue stem cell degenerates, or if a more differentiated cell reacquires stem cell. Once they enter your bloodstream, the stem cells travel to the bone. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but. Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering. The leading risk factors for the most prevalent forms of human cancer involve settings such as aging and chronic inflammation and which induce chronic increases in attempted cell renewal balkwill and coussens, 2004.
Essentials of cancer stem cells and conceptual modeling. The other cancer cells produced by cancer stem cells should follow many of the rules observed by daughter cells in normal tissues. Such an approach is significant since it was galen who promoted the. From the essentials to application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. The stem cell theory of cancer ludwig center stanford. Some researchers say that cancerous cells are like a caricature of normal cells. Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organspecific identifications, and their characteristic mechanisms.
Mesenchymal stem cells in cancer therapy sheds light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells msc in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell based therapies for cancer. Cancer stem cells wiley online books wiley online library. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissueorgan. Difference between tissue specific stem cells and embryonic stem cells is explained. A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Stem cells and cancer stem cells, volume 1 springer. It is emphasized that a cancer stem cell is a tumor initiating cell. Stem cell and bone marrow transplants macmillan cancer. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of. Lucie laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.
Cancer stem cells theories and practice is firmly grounded in the latest results on cancer stem cells cscs from worldclass cancer research laboratories, but its twentytwo chapters also tease apart. The main goal of the book is to provide readers with an. Louis, mo, usa using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulindependent diabetes called wolfram syndrome, researchers transformed the human stem cells into insulinproducing cells and used the geneediting tool crisprcas9 to correct a genetic defect that had caused the syndrome. Signalling pathways controlling liver size is discussed in this chapter, too. Within a malignant tumor or among the circulating cancerous cells of a leukemia, there can be a variety of types of cells.
Human embryonic stem cells and their applications receive particular attention, with explanations of the. Cancer stem cells may be the source of all the tumor cells present in a malignant tumor, the reason for the resistance to the chemotherapeutic agent used to treat the malignant tumor, and the source. Although the origin of the cancer stem cells is not identified yet, the concept of the cancer stem cells may allow new treatment options in the possible cure of the cancer. Stem cells and cancer stem cells, volume 8 therapeutic. However, in multiple myeloma and some types of leukemia, the stem cell transplant may work against cancer directly. The realization that cancers may rely on cancer stem cells that share the self.
Then you can start reading kindle books on your smartphone, tablet, or computer no kindle device required. Such an approach is significant since it was galen who promoted the use of logic, and in fact the full trivium, as an integral part of the practice of medicine. Stem cell transplants in cancer treatment national. Although the origin of the cancer stem cells is not identified yet, the concept of the. This volume was written by 85 contributors representing 14 countries the advantage of involving more than one author is to present different points of view on a specific controversial aspect of cancer cure and. An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It has also been suggested that cancer stem cells are more resistant to chemo and radiotherapy than other cells in a tumour. The discovery of stem cells has ignited a field of discovery in many human disease areas including diabetes, neurology, and cancer. Cancer stem cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells.
The nature and clinical relevance of cancer stem cells are timely topics covered with an appropriately broad and insightful brush in this comprehensive book devoted entirely to this subject. The recent book by laplane on cancer stem cells is a brilliantly wellcrafted introduction to the field from is a philosophical perspective. These include surface marker expression, side population, spheres formation, aldh activity, and numerous others. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissuespecific stem and. Scientists have tried for decades to understand cancer development in the context of therapeutic strategies. The knowledge about culture medium, isolation protocols and pluripotency related. This book discusses the emerging field of cancer stem cell. Cancer stem cells theories and practice is firmly grounded in the latest results on cancer stem cells cscs from worldclass cancer research laboratories, but its twentytwo chapters also tease apart cancer s vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance. How cancer stem cells are able to survive and thrive is a question that is being actively pursued by scientists who aim to develop new strategies that target these cells. Since the early 2000s they have been an intense cancer research focus. Cancer stem cell niche another topic which might be added is the theory of a cancer stem cell niche, stating that like normal stem cells also cancer stem cells need a specific environment to keep up their stem like state. Stem cells in our bodies act as reservoirs of cells that divide to produce new stem cells, as well as a myriad of different types of specialized cells, required to secure tissue renewal and function. Attacking cancer from the roots and millions of other books are available for amazon kindle. Cancer stem cells huiping liu bok 9780128038925 bokus.
Stem cells and cancer stem cells are 2 distinct, evolving, and promising areas of research. Definition of blood stem cell nci dictionary of cancer. The tissues from which stem cells have been derived for research have become controversial over the years. Framing the issue stem cells are undifferentiated cells that have the capacity to renew themselves and to specialize into various cell types, such as blood, muscle, and nerve cells. The book also explores innovative therapeutic strategies in. Stem cells is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. The full truth about cancer can only be understood, when we realize that most, if not all solid tumors are having their own cancer stem cells csc.
Cancer stem cells in breast cancer, brain tumors, certain forms of leukemia, and gastric tumor. Blood stem cells are found in the peripheral blood and the bone marrow. Stem cells and cancer stem cells, volume 2 stem cells and. Stem cell transplants do not usually work against cancer directly. Stem cells, cancer, and epigenetics stembook ncbi bookshelf. Cancer biologists believe that cancer stem cells, like other adult stem cells, can both divide into new stem cells and differentiate into more specialized cells. Cancer stem cells william l farrar explores the emerging field of research in cancer stem cells. The term itself was coined in a highly cited paper in 2001 by biologists tannishtha reya, sean j. Cancer stem cells cell biology and developmental biology. Cancer stem cells were first identified by john dick in acute myeloid leukemia in the late 1990s. Louis, mo, usa using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulindependent diabetes called wolfram syndrome, researchers transformed the. The specific types of stem cell singled out for discussion in this sixth volume include human mesenchymal, germ cellderived pluripotent, induced pluripotent, human umbilical cord bloodderived, breast tumor, and hematopoietic stem cells.
Stem cell transplants in cancer treatment national cancer. This authoritative book, written by a range of worldleading cancer researchers, provides a comprehensive overview of the cancer stem cell, its microenvironment, and how these insights will lead to novel clinical strategies. The discovery of normal adult stem cells, able to selfrenew and regenerate damaged tissue, has led to the idea that cancer may either originate from adult stem cells or contain stem celllike cells that are. It is pointed out that cancer stem cell is a cell type within a tumor that. Cancer cells may include cancer stem cells, a rare type of cells with indefinite potential for selfrenewal that forms tumor. Blood stem cells boost immunity by keeping a record of. Cancer stem cells have the capacity to selfrenew, to give rise to progeny that are different from them, and to utilize common signaling pathways. In a stem cell transplant, you receive healthy bloodforming stem cells through a needle in your vein. I praise the editor and the authors for this wonderful endeavor, rich of provocative ideas and challenging concepts, not only for a better understanding of basic cancer biology, but also for the future. Stem cells and cancer stem cells, volume 8 therapeutic applications in disease and injury. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology two fields that enhance, move, and evolve into each other continuously. Cancer stem cells may be the source of all the tumor cells. The transplantation of hepatic stem cells or cells differentiated from liver stem cells has been considered as an alternative to regular liver transplantation. The specific types of stem cell singled out for discussion in this sixth volume include human mesenchymal, germ cellderived pluripotent, induced pluripotent, human umbilical cord bloodderived.
The twentyeight chapters assembled in cancer stem cells the cutting edge summarize the work of. If a cancer treatment destroys the bulk of a tumour but leaves behind cancer stem cells, then those cancer stem cells can continue to selfrenew and can cause the tumour. The use of embryonic stem es cells in regenerative medicine is one of the most important promises of this decade. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissuespecific stem and progenitor. This detailed volume gathers a comprehensive collection of methods, protocols, and procedures used for the identification, characterization, and selection of cancer stem cells.
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